The pair, both aged in their 20s, were arrested after lengthy negotiations and as police raided five properties across Melbourne in connection with a drugs investigation.

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The siege began just after 6am when police attempted to arrest two men in Cumberland Drive in Maribyrnong.

The men refused to come out, prompting police to surround the unit. They were arrested about 10.30am.

Police said this morning that the raids had netted about 15 kilograms of methamphetamines worth about $10 million, loaded hand guns and about $60,000 cash across the properties, including a drugs lab at St Leonards, during the raids.

Another two men were arrested in connection with the drugs raids at Reservoir, Brunswick, Maribyrnong, Glenferrie and St Leonards.

Detective Superintendent Doug Fryer said the raids uncovered one of the most sophisticated drug labs officers had seen in a decade.

He said the discovery of the clandestine lab in St Leonards ‘‘should put a dent in the market’’.

‘‘Our clandestine laboratory squad say this is one of the most sophisticated labs they have seen in the last decade."