The figures show WorkSafe spent more than $700million on musculoskeletal injuries caused by accidents at workplaces in Melbourne suburbs and surrounds. The money paid for lost wages, and medical and other expenses.

Maribyrnong was 11th on the list, with costs put at $27million.

Hume fared second-highest among the municipalities in the region, its workplace injuries costing more than $60million.

WorkSafe's strategic programs director, Trevor Martin, says these injuries are normally overlooked when it comes to workplace safety.

"Injuries to the muscles, tissue, nerves and bones account for more than half of all workplace injuries in Victoria, but they are often overshadowed because there's no 'blood on the floor',"

Mr Martin said. "Lifting a box, climbing a stepladder or navigating a slippery surface at work might not set off alarm bells for most of us - but tasks like these cause thousands of Melbourne workers painful muscle and bone injuries every year."

WorkSafe's Tom Wood, who helps people cope with injuries, said: "These injuries make up a lot of my everyday work and as you can tell by the figures it [the injuries] cost a lot of money," Mr Wood said.

"Most of these injuries occur when people don't think they can do anything about a situation.

"Many businesses and employees are surprised with how easily injuries occur."

WorkSafe is encouraging businesses to be more aware of the damage musculoskeletal injuries can cause. "Our message to Melbourne's employers is that regardless of their industry or business, they need to be talking to their workforce, identifying risks and fixing them," Mr Martin said.